Merlin Mann is running a series of posts on taming your inbox. I took a couple hours to plow through, and brought my inbox from a ~1000 message backlog down to under 10 (cycling set). Johanna Rothman just started on it too. If you tend to have a large email inbox that leaves you thinking “I should do something about that,” I recommend reading these posts (and, ahem, doing something about your mail).